9IS9
human MTHFD2 in complex with LY374571
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | polymer | 319 | 34597.0 | 2 | UniProt (P13995) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (human) | |
| 2 | C, E (A, B) | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid | non-polymer | 433.4 | 2 | Chemie (9L9) | |||
| 3 | D, F (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 4 | G, H (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 350 (UniProt: P13995)
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | - | expression tag |
| Ser 33 | - | expression tag |
| His 34 | - | expression tag |
| Met 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69194.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2383.5 | |
| All* | Total formula weight | 71577.6 |
