9IRC

CyroEM structure of hSLC15A4+TASL+Fab235

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Solute carrier family 15 member 4	polymer	602	64834.1	1	UniProt (Q8N697) Pfam (PF00854)	Homo sapiens (human)	Peptide transporter 4,Peptide/histidine transporter 1,hPHT1
2	B (B)	TLR adapter interacting with SLC15A4 on the lysosome	polymer	170	19437.5	1	UniProt (Q9D3J9) Pfam (PF15133)	Mus musculus
3	C (H)	Fab235 heavy chain	polymer	120	13300.9	1		Mus musculus
4	D (L)	Fab235 light chain	polymer	108	11618.9	1		Mus musculus

Sequence modifications

A: 1 - 577 (UniProt: Q8N697)

PDB	External Database	Details
Lys 578	-	expression tag
Leu 579	-	expression tag
Gly 580	-	expression tag
Ser 581	-	expression tag
Glu 582	-	expression tag
Asn 583	-	expression tag
Leu 584	-	expression tag
Tyr 585	-	expression tag
Phe 586	-	expression tag
Gln 587	-	expression tag
Gly 588	-	expression tag
Gly 589	-	expression tag
Ser 590	-	expression tag
Gly 591	-	expression tag
Gly 592	-	expression tag
Ser 593	-	expression tag
Gly 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
His 600	-	expression tag
His 601	-	expression tag
His 602	-	expression tag

B: 35 - 129 (UniProt: Q9D3J9)

PDB	External Database	Details
Met 1	-	initiating methionine
Leu 2	-	expression tag
Ser 3	-	expression tag
Glu 4	-	expression tag
Gly 5	-	expression tag
Tyr 6	-	expression tag
Leu 7	-	expression tag
Ser 8	-	expression tag
Gly 9	-	expression tag
Leu 10	-	expression tag
Glu 11	-	expression tag
Tyr 12	-	expression tag
Trp 13	-	expression tag
Asn 14	-	expression tag
Asp 15	-	expression tag
Ile 16	-	expression tag
His 17	-	expression tag
Trp 18	-	expression tag
Asn 19	-	expression tag
Cys 20	-	expression tag
Ala 21	-	expression tag
Ser 22	-	expression tag
Tyr 23	-	expression tag
Asn 24	-	expression tag
Glu 25	-	expression tag
Pro 26	-	expression tag
Val 27	-	expression tag
Ala 28	-	expression tag
Gly 29	-	expression tag
Asp 30	-	expression tag
Gln 31	-	expression tag
Gly 32	-	expression tag
Lys 33	-	expression tag
Glu 34	-	expression tag
Lys 130	-	expression tag
Leu 131	-	expression tag
Gly 132	-	expression tag
Ser 133	-	expression tag
Glu 134	-	expression tag
Asn 135	-	expression tag
Leu 136	-	expression tag
Tyr 137	-	expression tag
Phe 138	-	expression tag
Gln 139	-	expression tag
Gly 140	-	expression tag
Gly 141	-	expression tag
Ser 142	-	expression tag
Gly 143	-	expression tag
Gly 144	-	expression tag
Ser 145	-	expression tag
Gly 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
Trp 155	-	expression tag
Ser 156	-	expression tag
His 157	-	expression tag
Pro 158	-	expression tag
Gln 159	-	expression tag
Phe 160	-	expression tag
Glu 161	-	expression tag
Lys 162	-	expression tag
Trp 163	-	expression tag
Ser 164	-	expression tag
His 165	-	expression tag
Pro 166	-	expression tag
Gln 167	-	expression tag
Phe 168	-	expression tag
Glu 169	-	expression tag
Lys 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109191.4
All*	Total formula weight	109191.4

*Water molecules are not included.