9IOW
Crystal Structure of SME-1 E166A Mutant in complex with Cefaclor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | beta-lactamase | polymer | 275 | 30345.3 | 1 | UniProt (Q54488) Pfam (PF00144) Pfam (PF13354) UniProt (by SIFTS) (P52682) | Serratia marcescens | SME E166A |
| 2 | B (A) | (R)-2-((R)-((R)-2-amino-2-phenylacetamido)(carboxy)methyl)-5-chloro-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | non-polymer | 385.8 | 1 | Chemie (Q6R) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 1 - 267 (UniProt: Q54488)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| Ala 143 | Glu 170 | engineered mutation |
| His 268 | - | expression tag |
| His 269 | - | expression tag |
| His 270 | - | expression tag |
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30345.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 456.7 | |
| All* | Total formula weight | 30802.0 |
