9IJS
Cryo-EM structure of the orphan GPR52 bound to beta-arrestin 1 in ligand-free state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G-protein coupled receptor 52 | polymer | 369 | 42400.6 | 1 | UniProt (Q9Y2T5) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (C) | Beta-arrestin-1 | polymer | 402 | 45148.4 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) | Homo sapiens (human) | Arrestin beta-1,Non-visual arrestin-2 |
| 3 | C (H) | scFv30 antibody | polymer | 266 | 28010.1 | 1 | synthetic construct |
Sequence modifications
A: 1 - 473 (UniProt: Q9Y2T5)
C: 2 - 393 (UniProt: P49407)
| PDB | External Database | Details |
|---|---|---|
| Trp 130 | Ala 130 | conflict |
| Pro 314 | Cys 314 | conflict |
| Ala 474 | - | expression tag |
| Arg 475 | - | expression tag |
| Gly 476 | - | expression tag |
| Arg 477 | - | expression tag |
| Pro 478 | - | expression tag |
| Leu 479 | - | expression tag |
| Pro 480 | - | expression tag |
| Glu 481 | - | expression tag |
| Thr 482 | - | expression tag |
| Gly 483 | - | expression tag |
| Gly 484 | - | expression tag |
| Gly 485 | - | expression tag |
| Asp 486 | - | expression tag |
| Glu 487 | - | expression tag |
| Sep 488 | - | expression tag |
| Ala 489 | - | expression tag |
| Tpo 490 | - | expression tag |
| Tpo 491 | - | expression tag |
| Ala 492 | - | expression tag |
| Sep 493 | - | expression tag |
| Sep 494 | - | expression tag |
| Sep 495 | - | expression tag |
| Leu 496 | - | expression tag |
| Ala 497 | - | expression tag |
| Lys 498 | - | expression tag |
| Asp 499 | - | expression tag |
| Thr 500 | - | expression tag |
| Ser 501 | - | expression tag |
| Ser 502 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Val 59 | Cys 59 | conflict |
| Ser 125 | Cys 125 | conflict |
| Leu 140 | Cys 140 | conflict |
| Val 150 | Cys 150 | conflict |
| Val 242 | Cys 242 | conflict |
| Val 251 | Cys 251 | conflict |
| Ser 269 | Cys 269 | conflict |
| Ser 368 | Asn 368 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 115559.0 | |
| All* | Total formula weight | 115559.0 |
