9IJD
Carazolol-activated human beta3 adrenergic receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37413.9 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 2 | B (N) | Camelid antibody VHH fragment | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 3 | C (D) | Single-chain Fv16 | polymer | 246 | 26206.2 | 1 | Homo sapiens | ||
| 4 | D (R) | Beta-3 adrenergic receptor | polymer | 321 | 34647.0 | 1 | UniProt (P13945) Pfam (PF00001) | Homo sapiens (human) | Beta-3 adrenoreceptor,Beta-3 adrenoceptor |
| 5 | E (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43320.8 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | Adenylate cyclase-stimulating G alpha protein |
| 6 | F (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 52 | 5731.6 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 7 | G (R) | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol | non-polymer | 298.4 | 1 | Chemie (CAU) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
R: 42 - 362 (UniProt: P13945)
A: 26 - 384 (UniProt: P04896)
| PDB | External Database | Details |
|---|---|---|
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 126 | Glu 126 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Lys 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Val 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Arg 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Met 25 | - | expression tag |
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| Asp 249 | Ala 249 | conflict |
| Asp 252 | Ser 252 | conflict |
| - | Asn 254 | deletion |
| - | Met 255 | deletion |
| - | Val 256 | deletion |
| - | Ile 257 | deletion |
| - | Arg 258 | deletion |
| - | Glu 259 | deletion |
| - | Asp 260 | deletion |
| - | Asn 261 | deletion |
| - | Gln 262 | deletion |
| - | Thr 263 | deletion |
| Ala 362 | Ile 372 | conflict |
| Ile 365 | Val 375 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 161205.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 298.4 | |
| All* | Total formula weight | 161503.3 |
