9IH5
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 8
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 213 | 24527.2 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 | polymer | 291 | 33644.2 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | (3~{R})-~{N}-(cyclobutylmethyl)-1-[6-[3-[4-(5-methoxypyridin-3-yl)-1,2,3-triazol-1-yl]oxetan-3-yl]pyridin-3-yl]piperidin-3-amine | non-polymer | 475.6 | 1 | Chemie (A1I4E) PubChem (172106383) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
B: 107 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Pro 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58171.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 475.6 | |
| All* | Total formula weight | 58647.0 |
