9IGB

Structure of human Bcl-xL in complex with small molecule inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Apoptosis regulator Bcl-2,Bcl-2-like protein 1	polymer	159	18202.1	4	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	E, F, G, H (A, B, C, D)	2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-1,3-thiazole-4-carboxylic acid	non-polymer		436.5	4	Chemie (A1I4A)

Sequence modifications

A, B, C, D: 3 - 27 (UniProt: P10415)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag

A, B, C, D: 28 - 45 (UniProt: Q07817)

PDB	External Database	Details
Ala 28	Ser 28	engineered mutation
Val 45	Met 45	engineered mutation

A, B, C, D: 86 - 155 (UniProt: Q07817)

PDB	External Database	Details
Leu 114	Ile 114	engineered mutation
Gly 121	Gln 121	engineered mutation
Ala 124	Glu 124	engineered mutation
Thr 125	Gln 125	engineered mutation

A, B, C, D: 156 - 199 (UniProt: P10415)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	72808.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1746.0
All*	Total formula weight	74554.5

*Water molecules are not included.