9IGA
Beta-hairpin macrocyclic peptide in complex with STAT1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Alpha of Signal transducer and activator of transcription 1-alpha/beta | polymer | 553 | 64088.6 | 1 | UniProt (P42224) Pfam (PF01017) Pfam (PF02864) Pfam (PF21354) Pfam (PF00017) | Homo sapiens (human) | Transcription factor ISGF-3 components p91/p84 |
| 2 | B (C) | OPG024 protein | polymer | 21 | 2345.7 | 1 | UniProt (P17356) Pfam (PF07020) | Orthopoxvirus vaccinia | |
| 3 | C (C) | ORTHO-XYLENE | non-polymer | 106.2 | 1 | Chemie (OXE) |
Sequence modifications
A: 132 - 684 (UniProt: P42224)
C: 11 - 30 (UniProt: P17356)
| PDB | External Database | Details |
|---|---|---|
| Ala 190 | Ser 190 | engineered mutation |
| Ala 393 | Glu 393 | engineered mutation |
| Ala 394 | Glu 394 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 13 | Ser 13 | conflict |
| Cys 28 | Thr 28 | conflict |
| Ala 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66434.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 106.2 | |
| All* | Total formula weight | 66540.4 |
