9IF6

Crystal structure of human SUMO E1 with large unit cell parameters in the P1 21 1 space group.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	SUMO-activating enzyme subunit 1	polymer	369	40960.5	2	UniProt (Q9UBE0) Pfam (PF00899)	Homo sapiens (human)	Ubiquitin-like 1-activating enzyme E1A
2	B, D (B, D)	SUMO-activating enzyme subunit 2	polymer	640	71314.5	2	UniProt (Q9UBT2) Pfam (PF00899) Pfam (PF14732) Pfam (PF16195)	Homo sapiens (human)	Anthracycline-associated resistance ARX,Ubiquitin-like 1-activating enzyme E1B,Ubiquitin-like modifier-activating enzyme 2
3	E, H (B, D)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4	F, I (B, D)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	G, J (B, D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	K, L, M, N (A, B, C, D)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A, C: 1 - 346 (UniProt: Q9UBE0)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	224550.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1193.8
All*	Total formula weight	225743.8

*Water molecules are not included.