9IBF
Crystal structure of hFcgammaRI-FAb complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | High affinity immunoglobulin gamma Fc receptor I | polymer | 280 | 31554.6 | 2 | UniProt (P12314) Pfam (PF13927) Pfam (PF13895) Pfam (PF00047) | Homo sapiens (human) | IgG Fc receptor I,Fc-gamma RI,FcRI,Fc-gamma RIA,FcgammaRIa |
| 2 | C, E (H, I) | Antibody Heavy chain FAb | polymer | 223 | 23704.6 | 2 | Mus musculus | ||
| 3 | D, F (L, M) | Antibody Light chain FAb | polymer | 220 | 23877.2 | 2 | Mus musculus | ||
| 4 | G, H, I (C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | K, N (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) | |||
| 7 | L, M, O, P, R (A, B, H, I) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) PubChem (312) | |||
| 8 | Q (L) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) |
Sequence modifications
A, B: 16 - 289 (UniProt: P12314)
| PDB | External Database | Details |
|---|---|---|
| Pro 20 | Thr 20 | engineered mutation |
| Lys 25 | Thr 25 | engineered mutation |
| Ser 38 | Thr 38 | engineered mutation |
| Pro 46 | Leu 46 | engineered mutation |
| Ile 63 | Thr 63 | engineered mutation |
| Thr 69 | Ser 69 | engineered mutation |
| His 71 | Arg 71 | engineered mutation |
| Glu 77 | Val 77 | engineered mutation |
| Asp 78 | Asn 78 | engineered mutation |
| Val 100 | Ile 100 | engineered mutation |
| Leu 114 | Phe 114 | engineered mutation |
| Met 160 | Ile 160 | engineered mutation |
| Ser 163 | Asn 163 | engineered mutation |
| Thr 195 | Asn 195 | engineered mutation |
| Thr 206 | Asn 206 | engineered mutation |
| Pro 207 | Leu 207 | engineered mutation |
| Asp 240 | Asn 240 | engineered mutation |
| His 283 | Leu 283 | engineered mutation |
| Gln 285 | Leu 285 | engineered mutation |
| His 290 | - | expression tag |
| His 291 | - | expression tag |
| His 292 | - | expression tag |
| His 293 | - | expression tag |
| His 294 | - | expression tag |
| His 295 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158272.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1859.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 858.0 | |
| All* | Total formula weight | 160990.6 |
