9I7U
Cryo-EM structure of NDUFA4 bound complex IV within the respirasome complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome c oxidase subunit 1 | polymer | 513 | 57104.9 | 1 | UniProt (P00395) Pfam (PF00115) | Homo sapiens (human) | Cytochrome c oxidase polypeptide I |
| 2 | B (B) | Cytochrome c oxidase subunit 2 | polymer | 227 | 25580.9 | 1 | UniProt (P00403) Pfam (PF02790) Pfam (PF00116) | Homo sapiens (human) | Cytochrome c oxidase polypeptide II |
| 3 | C (C) | Cytochrome c oxidase subunit 3 | polymer | 261 | 30003.7 | 1 | UniProt (P00414) Pfam (PF00510) | Homo sapiens (human) | Cytochrome c oxidase polypeptide III |
| 4 | D (D) | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | polymer | 169 | 19609.8 | 1 | UniProt (P13073) Pfam (PF02936) | Homo sapiens (human) | Cytochrome c oxidase polypeptide IV,Cytochrome c oxidase subunit IV isoform 1,COX IV-1 |
| 5 | E (E) | Cytochrome c oxidase subunit 5A, mitochondrial | polymer | 150 | 16785.2 | 1 | UniProt (P20674) Pfam (PF02284) | Homo sapiens (human) | Cytochrome c oxidase polypeptide Va |
| 6 | F (F) | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 129 | 13714.7 | 1 | UniProt (P10606) Pfam (PF01215) | Homo sapiens (human) | Cytochrome c oxidase polypeptide Vb |
| 7 | G (G) | Cytochrome c oxidase subunit 6A1, mitochondrial | polymer | 109 | 12173.9 | 1 | UniProt (P12074) Pfam (PF02046) | Homo sapiens (human) | Cytochrome c oxidase polypeptide VIa-liver,Cytochrome c oxidase subunit VIA-liver,COX VIa-L |
| 8 | H (H) | Cytochrome c oxidase subunit 6B1 | polymer | 86 | 10204.4 | 1 | UniProt (P14854) Pfam (PF02297) | Homo sapiens (human) | Cytochrome c oxidase subunit VIb isoform 1,COX VIb-1 |
| 9 | I (I) | Cytochrome c oxidase subunit 6C | polymer | 75 | 8798.5 | 1 | UniProt (P09669) Pfam (PF02937) | Homo sapiens (human) | Cytochrome c oxidase polypeptide VIc |
| 10 | J (J) | Cytochrome c oxidase subunit 7A2, mitochondrial | polymer | 83 | 9410.0 | 1 | UniProt (P14406) Pfam (PF02238) | Homo sapiens (human) | Cytochrome c oxidase subunit VIIa-liver/heart,Cytochrome c oxidase subunit VIIa-L,Cytochrome c oxidase subunit VIIaL |
| 11 | K (K) | Cytochrome c oxidase subunit 7B, mitochondrial | polymer | 80 | 9172.5 | 1 | UniProt (P24311) Pfam (PF05392) | Homo sapiens (human) | Cytochrome c oxidase polypeptide VIIb |
| 12 | L (L) | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 63 | 7256.5 | 1 | UniProt (P15954) Pfam (PF02935) | Homo sapiens (human) | Cytochrome c oxidase polypeptide VIIc |
| 13 | M (M) | Cytochrome c oxidase subunit 8A, mitochondrial | polymer | 69 | 7589.1 | 1 | UniProt (P10176) Pfam (PF02285) | Homo sapiens (human) | Cytochrome c oxidase polypeptide VIII-liver/heart,Cytochrome c oxidase subunit 8-2 |
| 14 | N (N) | Cytochrome c oxidase subunit NDUFA4 | polymer | 81 | 9381.8 | 1 | UniProt (O00483) Pfam (PF06522) | Homo sapiens (human) | Complex I-MLRQ,CI-MLRQ,NADH-ubiquinone oxidoreductase MLRQ subunit |
| 15 | O, T, U (A, B) | COPPER (II) ION | non-polymer | 63.5 | 3 | Chemie (CU) | |||
| 16 | P (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 17 | Q (A) | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE | non-polymer | 749.0 | 1 | Chemie (PGV) | |||
| 18 | R, S (A) | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 19 | V, W, X, Y (C) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 4 | Chemie (PEE) | |||
| 20 | Z (F) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 21 | AA (N) | CARDIOLIPIN | non-polymer | 1464.0 | 1 | Chemie (CDL) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 236785.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 7175.2 | |
| All* | Total formula weight | 243961.0 |
