9I54

Dopamine 1 receptor:GaS complex bound to 24

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	394	45755.5	1	UniProt (P63092) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-stimulating G alpha protein
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	350	38636.2	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (R)	Beta-2 adrenergic receptor,D(1A) dopamine receptor	polymer	536	59074.7	1	UniProt (P07550) UniProt (P21728) Pfam (PF00001)	Homo sapiens (human)	Beta-2 adrenoreceptor,Beta-2 adrenoceptor,Dopamine D1 receptor
5	E (R)	6-(3-fluoranyl-5-furo[3,2-c]pyridin-4-yloxy-pyridin-2-yl)-1,5-dimethyl-pyrimidine-2,4-dione	non-polymer		368.3	1	Chemie (A1IZV)
6	F (R)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 394 (UniProt: P63092)

PDB	External Database	Details
Ala 226	Gly 226	conflict
Ser 366	Ala 366	variant

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -8	-	initiating methionine
Gly -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 341	-	expression tag

R: -42 - -13 (UniProt: P07550)

PDB	External Database	Details
Met -81	-	initiating methionine
Asp -80	-	expression tag
Ser -79	-	expression tag
Lys -78	-	expression tag
Gly -77	-	expression tag
Ser -76	-	expression tag
Ser -75	-	expression tag
Gln -74	-	expression tag
Lys -73	-	expression tag
Gly -72	-	expression tag
Ser -71	-	expression tag
Arg -70	-	expression tag
Leu -69	-	expression tag
Leu -68	-	expression tag
Leu -67	-	expression tag
Leu -66	-	expression tag
Leu -65	-	expression tag
Val -64	-	expression tag
Val -63	-	expression tag
Ser -62	-	expression tag
Asn -61	-	expression tag
Leu -60	-	expression tag
Leu -59	-	expression tag
Leu -58	-	expression tag
Cys -57	-	expression tag
Gln -56	-	expression tag
Gly -55	-	expression tag
Val -54	-	expression tag
Val -53	-	expression tag
Ser -52	-	expression tag
Asp -51	-	expression tag
Tyr -50	-	expression tag
Lys -49	-	expression tag
Asp -48	-	expression tag
Asp -47	-	expression tag
Asp -46	-	expression tag
Asp -45	-	expression tag
Lys -44	-	expression tag
Asp -43	-	expression tag
Gly -12	-	linker
Gly -11	-	linker
Ser -10	-	linker
Glu -9	-	linker
Asn -8	-	linker
Leu -7	-	linker
Tyr -6	-	linker
Phe -5	-	linker
Gln -4	-	linker
Gly -3	-	linker
Gly -2	-	linker
Gly -1	-	linker
Ser 0	-	linker

R: 1 - 446 (UniProt: P21728)

PDB	External Database	Details
His 447	-	expression tag
His 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	151327.6
Non-Polymers*	Number of molecules	1
	Total formula weight	368.3
All*	Total formula weight	151695.9

*Water molecules are not included.