9I0O

Cryo-EM structure of human sortilin ectodomain in complex with a thyroglobulin C-terminal peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sortilin	polymer	742	82940.6	1	UniProt (Q99523) Pfam (PF15902) Pfam (PF15901)	Homo sapiens (human)	100 kDa NT receptor,Glycoprotein 95,Gp95,Neurotensin receptor 3,NT3,NTR3
2	B (B)	Thyroglobulin	polymer	20	2211.5	1	UniProt (P01266)	Homo sapiens	Tg
3	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 1 - 723 (UniProt: Q99523)

PDB	External Database	Details
Glu 724	-	expression tag
Asn 725	-	expression tag
Leu 726	-	expression tag
Tyr 727	-	expression tag
Phe 728	-	expression tag
Gln 729	-	expression tag
Ser 730	-	expression tag
Ala 731	-	expression tag
Gly 732	-	expression tag
His 733	-	expression tag
His 734	-	expression tag
His 735	-	expression tag
His 736	-	expression tag
His 737	-	expression tag
His 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85152.0
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	86222.0

*Water molecules are not included.