9HWT
Crystal structure of the Keap1 Kelch domain in complex with the small molecule UCAB#985 at 1.65 Angstrom resolution
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kelch-like ECH-associated protein 1 | polymer | 304 | 33362.3 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) | Mus musculus (house mouse) | Cytosolic inhibitor of Nrf2,INrf2 |
| 2 | B (A) | (3~{S})-3-[7-[2-(cycloheptylamino)-2-oxidanylidene-ethoxy]naphthalen-2-yl]-3-(6-methyl-1,3-benzodioxol-5-yl)propanoic acid | non-polymer | 503.6 | 1 | Chemie (A1IX4) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I (A) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
| PDB | External Database | Details |
|---|---|---|
| Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33362.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 965.6 | |
| All* | Total formula weight | 34327.9 |
