9HVE
Native human eIF2-eIF2B complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (F, E) | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) Pfam (PF25084) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit gamma |
| 2 | C, K (K, L) | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 315 | 36161.2 | 2 | UniProt (P05198) Pfam (PF00575) Pfam (PF07541) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha |
| 3 | D, L (I, J) | Translation initiation factor eIF2B subunit epsilon | polymer | 721 | 80466.6 | 2 | UniProt (Q13144) Pfam (PF02020) | Homo sapiens (human) | eIF2B GDP-GTP exchange factor subunit epsilon |
| 4 | E, M (O, P) | Eukaryotic translation initiation factor 2 subunit 3 | polymer | 472 | 51178.4 | 2 | UniProt (P41091) Pfam (PF00009) Pfam (PF03144) Pfam (PF09173) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX |
| 5 | F, N (D, C) | Translation initiation factor eIF2B subunit beta | polymer | 351 | 39039.5 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (human) | S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta |
| 6 | G, O (A, B) | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit alpha |
| 7 | H, P (H, G) | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (human) | eIF-2B GDP-GTP exchange factor subunit delta |
| 8 | I, J (M, N) | Eukaryotic translation initiation factor 2 subunit 2 | polymer | 333 | 38454.5 | 2 | UniProt (P20042) Pfam (PF01873) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit beta,eIF-2-beta |
| 9 | Q, R (F, E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 773997.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1046.4 | |
| All* | Total formula weight | 775043.9 |
