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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9HUM

a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after short GABA treatment

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)		Green fluorescent protein,Gamma-aminobutyric acid receptor subunit alpha-5polymer67976207.32UniProt (P42212)
UniProt (P31644)		Aequorea victoriaGABA(A) receptor subunit alpha-5,GABAAR subunit alpha-5
2B, C, E
(B, C, E)		Gamma-aminobutyric acid receptor subunit beta-3,Green fluorescent proteinpolymer62371073.43UniProt (P28472)
UniProt (P42212)		Homo sapiens (human)GABA(A) receptor subunit beta-3,GABAAR subunit beta-3
3F
(P)		Megabody 25polymer54158275.11Escherichia coli
4G
(F)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
5H, J, O
(G, I, N)		beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
6I, N
(H, M)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.02In PDB
GlyTouCan (G09724ZC)
7K
(J)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.01In PDB
8L
(K)		beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.51In PDB
GlyTouCan (G44266EX)
9M
(L)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G35932AR)
10P, S
(B, E)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.12Chemie (ABU)
11Q
(C)		4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACIDnon-polymer238.31Chemie (EPE)
12R
(D)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
Sequence modifications
A, D: -287 - -50 (UniProt: P42212)
PDBExternal DatabaseDetails
Met -315-initiating methionine
Arg -314-expression tag
Lys -313-expression tag
Ser -312-expression tag
Pro -311-expression tag
Gly -310-expression tag
Leu -309-expression tag
Ser -308-expression tag
Asp -307-expression tag
Cys -306-expression tag
Leu -305-expression tag
Trp -304-expression tag
Ala -303-expression tag
Trp -302-expression tag
Ile -301-expression tag
Leu -300-expression tag
Leu -299-expression tag
Leu -298-expression tag
Ser -297-expression tag
Thr -296-expression tag
Leu -295-expression tag
Thr -294-expression tag
Gly -293-expression tag
Arg -292-expression tag
Ser -291-expression tag
Tyr -290-expression tag
Gly -289-expression tag
Gln -288-expression tag
Arg -258Ser 30engineered mutation
Asn -249Tyr 39engineered mutation
Leu -224Phe 64engineered mutation
Thr -223Ser 65engineered mutation
Arg -208Gln 80engineered mutation
Ser -189Phe 99engineered mutation
Thr -183Asn 105engineered mutation
Phe -143Tyr 145engineered mutation
Thr -135Met 153engineered mutation
Ala -125Val 163engineered mutation
Val -117Ile 171engineered mutation
Val -82Ala 206engineered mutation
Ala -49-linker
Ala -48-linker
Asn -47-linker
Ala -46-linker
Leu -45-linker
Ala -44-linker
Ala -43-linker
Trp -42-linker
Ser -41-linker
His -40-linker
Pro -39-linker
Gln -38-linker
Phe -37-linker
Glu -36-linker
Lys -35-linker
Gly -34-linker
Gly -33-linker
Gly -32-linker
Ser -31-linker
Gly -30-linker
Gly -29-linker
Gly -28-linker
Ser -27-linker
Gly -26-linker
Gly -25-linker
Gly -24-linker
Ser -23-linker
Trp -22-linker
Ser -21-linker
His -20-linker
Pro -19-linker
Gln -18-linker
Phe -17-linker
Glu -16-linker
Lys -15-linker
Ser -14-linker
Ser -13-linker
Ser -12-linker
Asn -11-linker
Asn -10-linker
Asn -9-linker
Asn -8-linker
Asn -7-linker
Glu -6-linker
Asn -5-linker
Leu -4-linker
Tyr -3-linker
Phe -2-linker
Gln -1-linker
Ala 0-linker
A, D: 1 - 313 (UniProt: P31644)
A, D: 322 - 363 (UniProt: P31644)
PDBExternal DatabaseDetails
Lys 314-linker
Ser 315-linker
Gln 316-linker
Pro 317-linker
Ala 318-linker
Arg 319-linker
Ala 320-linker
Ala 321-linker
B, C, E: -24 - 307 (UniProt: P28472)
PDBExternal DatabaseDetails
Ser 308-linker
Gln 309-linker
Pro 310-linker
Gly 311-linker
Arg 312-linker
Ala 313-linker
Met 314-linker
Val 315-linker
B, C, E: 316 - 552 (UniProt: P42212)
PDBExternal DatabaseDetails
Met 332Leu 18engineered mutation
Arg 339His 25engineered mutation
Arg 344Ser 30engineered mutation
Val 346Glu 32engineered mutation
His 353Tyr 39engineered mutation
Ser 364Thr 50engineered mutation
Leu 378Phe 64engineered mutation
Ser 419Asn 105engineered mutation
Val 438Glu 124engineered mutation
Thr 442Ile 128engineered mutation
Met 459Tyr 145engineered mutation
Val 461Ser 147engineered mutation
Gly 462His 148engineered mutation
Thr 467Met 153engineered mutation
Ala 477Val 163engineered mutation
Glu 480Lys 166engineered mutation
Val 485Ile 171engineered mutation
Gly 489Ser 175engineered mutation
Ser 506Pro 192engineered mutation
Val 517Thr 203engineered mutation
Val 519Ser 205engineered mutation
Lys 520Ala 206engineered mutation
Arg 538Val 224engineered mutation
Pro 545His 231engineered mutation
Gly 553-expression tag
Arg 554-expression tag
Ala 555-expression tag
Ala 556-expression tag
Ala 557-expression tag
Ile 558-expression tag
Asp 559-expression tag
Arg 560-expression tag
Trp 561-expression tag
Ser 562-expression tag
Arg 563-expression tag
Ile 564-expression tag
Val 565-expression tag
Phe 566-expression tag
Pro 567-expression tag
Phe 568-expression tag
Thr 569-expression tag
Phe 570-expression tag
Ser 571-expression tag
Leu 572-expression tag
Phe 573-expression tag
Asn 574-expression tag
Leu 575-expression tag
Val 576-expression tag
Tyr 577-expression tag
Trp 578-expression tag
Leu 579-expression tag
Tyr 580-expression tag
Tyr 581-expression tag
Val 582-expression tag
Asn 583-expression tag
Ser 584-expression tag
Arg 585-expression tag
Glu 586-expression tag
Asn 587-expression tag
Leu 588-expression tag
Tyr 589-expression tag
Phe 590-expression tag
Gln 591-expression tag
Ala 592-expression tag
His 593-expression tag
His 594-expression tag
His 595-expression tag
His 596-expression tag
His 597-expression tag
His 598-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight423910.0
BranchedNumber of molecules9
Total formula weight6413.9
Non-Polymers*Number of molecules4
Total formula weight665.8
All*Total formula weight430989.6
*Water molecules are not included.

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PDB entries from 2026-01-14

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