9HUE
Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor ORG25543
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium- and chloride-dependent glycine transporter 2 | polymer | 613 | 68976.0 | 1 | UniProt (Q9Y345) | Homo sapiens (human) | GlyT-2,GlyT2,Solute carrier family 6 member 5 |
| 2 | B (A) | ~{N}-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-phenylmethoxy-benzamide | non-polymer | 412.5 | 1 | Chemie (A1EF1) | |||
| 3 | C, F (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) | |||
| 4 | D, E (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 5 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | I (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 186 - 797 (UniProt: Q9Y345)
| PDB | External Database | Details |
|---|---|---|
| Met 185 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 68976.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2217.7 | |
| All* | Total formula weight | 71193.7 |
