9HS7
Anti-HIV-1 chimeric miniprotein mimicking the N-terminal half of gp41 NHR with an extended region targeting the MPER
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transmembrane protein gp41 | polymer | 140 | 15447.8 | 1 | UniProt (P19551) | Human immunodeficiency virus type 1 (BRU ISOLATE) | TM,Glycoprotein 41,gp41 |
| 2 | B (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 3 | C (A) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 2 - 40 (UniProt: P19551)
A: 88 - 130 (UniProt: P19551)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Cys 3 | Met 528 | engineered mutation |
| Lys 10 | Leu 535 | engineered mutation |
| Lys 17 | Leu 542 | engineered mutation |
| Lys 24 | Gln 549 | engineered mutation |
| Lys 31 | Ala 556 | engineered mutation |
| Ile 35 | Gln 560 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 41 | - | linker |
| Gly 42 | - | linker |
| Leu 43 | - | linker |
| Ile 44 | - | linker |
| Cys 45 | - | linker |
| Gly 46 | - | linker |
| Pro 47 | - | linker |
| Gln 48 | - | linker |
| Leu 49 | - | linker |
| Leu 50 | - | linker |
| His 51 | - | linker |
| Gln 52 | - | linker |
| Ile 53 | - | linker |
| Ala 54 | - | linker |
| Glu 55 | - | linker |
| Ile 56 | - | linker |
| Glu 57 | - | linker |
| Arg 58 | - | linker |
| Glu 59 | - | linker |
| Leu 60 | - | linker |
| Asn 61 | - | linker |
| Asn 62 | - | linker |
| Gln 63 | - | linker |
| Glu 64 | - | linker |
| Gln 65 | - | linker |
| Glu 66 | - | linker |
| Ile 67 | - | linker |
| Gly 68 | - | linker |
| Ser 69 | - | linker |
| Leu 70 | - | linker |
| Lys 71 | - | linker |
| Gln 72 | - | linker |
| Arg 73 | - | linker |
| Ala 74 | - | linker |
| Gln 75 | - | linker |
| Val 76 | - | linker |
| Glu 77 | - | linker |
| Lys 78 | - | linker |
| Thr 79 | - | linker |
| Met 80 | - | linker |
| Ser 81 | - | linker |
| Ala 82 | - | linker |
| Ala 83 | - | linker |
| Ser 84 | - | linker |
| Gly 85 | - | linker |
| Cys 86 | - | linker |
| Gly 87 | - | linker |
| Pro 90 | Ala 530 | engineered mutation |
| Asp 96 | Thr 536 | engineered mutation |
| Asp 107 | Val 547 | engineered mutation |
| Lys 114 | Leu 554 | engineered mutation |
| Ile 120 | Gln 560 | engineered mutation |
| Lys 121 | Gln 561 | engineered mutation |
| Cys 128 | Val 568 | engineered mutation |
| Gly 131 | - | expression tag |
| Gly 132 | - | expression tag |
| Gly 133 | - | expression tag |
| Ser 134 | - | expression tag |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15447.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 106.1 | |
| All* | Total formula weight | 15553.9 |
