9HQS
Variant R313K of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the product UMP at 1.1 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Uridine 5'-monophosphate synthase | polymer | 258 | 28175.7 | 1 | UniProt (P11172) Pfam (PF00215) | Homo sapiens (human) | UMP synthase |
| 2 | B (A) | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (U5P) PubChem (6030) | |||
| 3 | C (A) | PROLINE | non-polymer | 115.1 | 1 | Chemie (PRO) PubChem (145742) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | water | water | 18.0 | 272 | Chemie (HOH) |
Sequence modifications
A: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Met 223 | - | initiating methionine |
| Lys 313 | Arg 313 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28175.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 531.4 | |
| All* | Total formula weight | 28707.1 |
