9HOJ
Variant H283A of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP and the product UMP at 1.15 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Uridine 5'-monophosphate synthase | polymer | 258 | 28136.6 | 2 | UniProt (P11172) | Homo sapiens (human) | UMP synthase |
| 2 | C, F (A, B) | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 2 | Chemie (U5P) PubChem (6030) | |||
| 3 | D, G (A, B) | PROLINE | non-polymer | 115.1 | 2 | Chemie (PRO) PubChem (145742) | |||
| 4 | E, H (A, B) | OROTIDINE-5'-MONOPHOSPHATE | non-polymer | 368.2 | 2 | Chemie (OMP) PubChem (160617) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 678 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Met 223 | - | initiating methionine |
| Ala 283 | His 283 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56273.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1615.0 | |
| All* | Total formula weight | 57888.2 |
