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9HNE

Cereblon in complex with DDB1, GSPT1 and Compound-1

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3Apolymer19721851.72UniProt (P15170)
Pfam (PF03144)
Pfam (PF22594)
Homo sapiens (human)Eukaryotic peptide chain release factor subunit 3a,eRF3a,G1 to S phase transition protein 1 homolog
2B, E
(B, E)
DNA damage-binding protein 1polymer1140127097.52UniProt (Q16531)
Pfam (PF10433)
Pfam (PF03178)
Homo sapiens (human)DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3C, F
(C, F)
Protein cereblonpolymer40446408.32UniProt (Q96SW2)
Pfam (PF02190)
Pfam (PF03226)
Homo sapiens (human)
4G, I
(C, F)
ZINC IONnon-polymer65.42Chemie (ZN)
5H, J
(C, F)
2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-6-fluoranyl-1-oxidanylidene-3~{H}-isoindole-5-carboxylic acidnon-polymer306.22Chemie (A1IWG)
Sequence modifications
C, F: 40 - 442 (UniProt: Q96SW2)
PDBExternal DatabaseDetails
Ser 39-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight390714.9
Non-Polymers*Number of molecules4
Total formula weight743.3
All*Total formula weight391458.2
*Water molecules are not included.

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PDB entries from 2025-12-03

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