9HMR

KRAS-G12V-D92C covalently bound to BI-1830

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform 2B of GTPase KRas	polymer	170	19336.8	4	UniProt (P01116) Pfam (PF00071)	Homo sapiens (human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	E, J, K, P (A, B, C, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	4	Chemie (GDP)
3	F, H, M, N (A, B, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4	G, I, L, O (A, B, C, D)	1-[4-[2-[(4-bromanyl-2-methyl-phenyl)amino]ethanoyl]piperazin-1-yl]propan-1-one	non-polymer		368.3	4	Chemie (A1IWE)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	374	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
Gly 0	-	expression tag
Val 12	Gly 12	engineered mutation
Ser 51	Cys 51	engineered mutation
Leu 80	Cys 80	engineered mutation
Cys 92	Asp 92	engineered mutation
Ser 118	Cys 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	77347.3
Non-Polymers*	Number of molecules	12
	Total formula weight	3494.2
All*	Total formula weight	80841.5

*Water molecules are not included.