9HKT

Drosophila melanogaster insulin receptor ectodomain in complex with one DILP2 molecule

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Insulin-like receptor	polymer	1068	120074.6	2	UniProt (P09208)	Drosophila melanogaster (fruit fly)	dIR,dInr,dIRH
2	C (G)	Probable insulin-like peptide 2	polymer	26	3025.6	1	UniProt (Q9VT51)	Drosophila melanogaster	dILP2,Insulin-related peptide 2
3	D (H)	Probable insulin-like peptide 2	polymer	24	2750.2	1	UniProt (Q9VT51)	Drosophila melanogaster	dILP2,Insulin-related peptide 2
4	E, F, G, H (C, D, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
5	I, J, K, L, M... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	17	Chemie (NAG)

Sequence modifications

A, B: 264 - 1310 (UniProt: P09208)

PDB	External Database	Details
Met 263	-	initiating methionine
Asp 1311	-	expression tag
Glu 1312	-	expression tag
Val 1313	-	expression tag
Leu 1314	-	expression tag
Phe 1315	-	expression tag
Gln 1316	-	expression tag
Gly 1317	-	expression tag
Pro 1318	-	expression tag
Ser 1319	-	expression tag
Arg 1320	-	expression tag
Ser 1321	-	expression tag
Ala 1322	-	expression tag
Trp 1323	-	expression tag
Ser 1324	-	expression tag
His 1325	-	expression tag
Pro 1326	-	expression tag
Gln 1327	-	expression tag
Phe 1328	-	expression tag
Glu 1329	-	expression tag
Lys 1330	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	245925.1
Branched	Number of molecules	4
	Total formula weight	1697.6
Non-Polymers*	Number of molecules	17
	Total formula weight	3760.5
All*	Total formula weight	251383.2

*Water molecules are not included.