9HK5

Structure of a mutant of human protein kinase CK2alpha' that equals its isoenzyme CK2alpha in affinity to the regulatory subunit CK2beta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Casein kinase II subunit alpha'	polymer	364	42908.0	1	UniProt (P19784) Pfam (PF00069)	Homo sapiens (human)	CK II alpha'
2	B, D (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	C (A)	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	non-polymer		349.8	1	Chemie (3NG)
4	E (A)	water	water		18.0	337	Chemie (HOH)

Sequence modifications

A: 1 - 350 (UniProt: P19784)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Val 32	Pro 32	engineered mutation
Ile 83	Val 83	engineered mutation
Ile 101	Thr 101	engineered mutation
Ser 336	Cys 336	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42908.0
Non-Polymers*	Number of molecules	3
	Total formula weight	473.9
All*	Total formula weight	43381.9

*Water molecules are not included.