9HH5
Crystal Structure of nsp15 Endoribonuclease from SARS CoV-2 in Complex with Sepantronium (YM-155)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replicase polyprotein 1ab | polymer | 346 | 38856.3 | 1 | UniProt (A0A8B1IYC0) Pfam (PF19219) Pfam (PF19216) Pfam (PF19215) UniProt (by SIFTS) (A0A8B6RWT5) | Severe acute respiratory syndrome coronavirus 2 | ORF1ab polyprotein |
| 2 | B (B) | Nsp15 - Uridylate-specific endoribonuclease | polymer | 268 | 29810.9 | 1 | Pfam (PF19219) Pfam (PF19216) Pfam (PF19215) UniProt (by SIFTS) (A0A8B6RLU5) | Severe acute respiratory syndrome coronavirus 2 | |
| 3 | C, E (A, B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 4 | D (A) | 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione | non-polymer | 363.4 | 1 | Chemie (GXU) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A: 2 - 346 (UniProt: A0A8B1IYC0)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68667.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 607.7 | |
| All* | Total formula weight | 69274.8 |
