9HGM
Structure of human DNMT2 with bound allosteric inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | tRNA (cytosine(38)-C(5))-methyltransferase | polymer | 348 | 39767.9 | 2 | UniProt (O14717) Pfam (PF00145) | Homo sapiens (human) | DNA (cytosine-5)-methyltransferase-like protein 2,Dnmt2,DNA methyltransferase homolog HsaIIP,DNA MTase homolog HsaIIP,M.HsaIIP,PuMet |
| 2 | C, E (A, B) | 4-ethyl-~{N}-[[1-[[(2~{R})-1-(1~{H}-indol-3-yl)-4-[[2-(methylamino)-2-oxidanylidene-ethyl]amino]-4-oxidanylidene-butan-2-yl]carbamoyl]cyclopropyl]methyl]benzamide | non-polymer | 517.6 | 2 | Chemie (A1IUL) | |||
| 3 | D, F (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 391 (UniProt: O14717)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| - | Val 192 | deletion |
| - | His 193 | deletion |
| - | Pro 194 | deletion |
| - | Gln 195 | deletion |
| - | Lys 196 | deletion |
| - | Tyr 197 | deletion |
| - | Ala 198 | deletion |
| - | Met 199 | deletion |
| - | Asp 200 | deletion |
| - | Val 201 | deletion |
| - | Glu 202 | deletion |
| - | Asn 203 | deletion |
| - | Lys 204 | deletion |
| - | Ile 205 | deletion |
| - | Gln 206 | deletion |
| - | Glu 207 | deletion |
| - | Lys 208 | deletion |
| - | Asn 209 | deletion |
| - | Val 210 | deletion |
| - | Glu 211 | deletion |
| - | Pro 212 | deletion |
| - | Asn 213 | deletion |
| - | Ile 214 | deletion |
| - | Ser 215 | deletion |
| - | Phe 216 | deletion |
| - | Asp 217 | deletion |
| - | Gly 218 | deletion |
| - | Ser 219 | deletion |
| - | Ile 220 | deletion |
| - | Gln 221 | deletion |
| - | Cys 222 | deletion |
| - | Ser 223 | deletion |
| - | Gly 224 | deletion |
| - | Lys 225 | deletion |
| - | Asp 226 | deletion |
| - | Ala 227 | deletion |
| - | Ile 228 | deletion |
| - | Leu 229 | deletion |
| - | Phe 230 | deletion |
| - | Lys 231 | deletion |
| - | Leu 232 | deletion |
| - | Glu 233 | deletion |
| - | Thr 234 | deletion |
| - | Ala 235 | deletion |
| - | Glu 236 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79535.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1219.4 | |
| All* | Total formula weight | 80755.2 |
