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9HG4

NACHT domain of NLRP3 in complex with DFV890

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
NACHT, LRR and PYD domains-containing protein 3polymer55064156.31UniProt (Q96P20)
Pfam (PF14484)
Pfam (PF05729)
Pfam (PF17779)
Pfam (PF17776)
Homo sapiens (human)Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
2B
(A)
1-[azanyl-oxidanylidene-[2-(2-oxidanylpropan-2-yl)-1,3-thiazol-5-yl]-$l^{6}-sulfanylidene]-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)ureanon-polymer420.51Chemie (A1IUG)
3C
(A)
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
4D
(A)
waterwater18.076Chemie (HOH)
Sequence modifications
A: 131 - 679 (UniProt: Q96P20)
PDBExternal DatabaseDetails
Gly 130-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight64156.3
Non-Polymers*Number of molecules2
Total formula weight847.8
All*Total formula weight65004.1
*Water molecules are not included.

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PDB entries from 2025-06-11

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