Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 414 | 48028.9 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 313 | 36491.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (human) | SRB11 homolog,hSRB11 |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | E (A) | 4-[(3~{S})-3-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]piperidin-1-yl]carbonyl-1~{H}-pyrrole-2-carbonitrile | non-polymer | 368.4 | 1 | Chemie (A1IS8) | |||
| 6 | F, G (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 275 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Gly -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Met -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -29 | - | expression tag |
| Ser -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Met -26 | - | expression tag |
| Lys -25 | - | expression tag |
| Glu -24 | - | expression tag |
| Thr -23 | - | expression tag |
| Ala -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Lys -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Arg -16 | - | expression tag |
| Gln -15 | - | expression tag |
| His -14 | - | expression tag |
| Met -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Thr -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84520.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 770.9 | |
| All* | Total formula weight | 85290.9 |
