9H4S

Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form II)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Zona pellucida sperm-binding protein 2	polymer	112	12994.6	2	UniProt (P20239)	Mus musculus (house mouse)	Zona pellucida glycoprotein 2,Zp-2,Zona pellucida protein A
2	B, E (H, X)	Heavy chain variable (VH) domain of anti-ZP2 monoclonal antibody IE-3	polymer	123	13290.5	2		Rattus norvegicus
3	C, F (L, Y)	Light chain variable (VL) domain of anti-ZP2 monoclonal antibody IE-3	polymer	117	12847.2	2		Rattus norvegicus
4	G, H, I, J, K... (A, H, L, B, X...)	water	water		18.0	308	Chemie (HOH)

Sequence modifications

A, B: 35 - 138 (UniProt: P20239)

PDB	External Database	Details
Ser 83	Asn 83	engineered mutation
Leu 139	-	expression tag
Glu 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	78264.8
All*	Total formula weight	78264.8

*Water molecules are not included.