9H4O
Crystal structure of IL-17A in complex with compound 11
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-17A | polymer | 123 | 14251.1 | 4 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | E, F, G, I, J... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | H, K (B, C) | (E)-N-[(1S)-1-[4,4-bis(fluoranyl)cyclohexyl]-2-oxidanylidene-2-[[5-[[(4S)-2-oxidanylidene-4-(trifluoromethyl)imidazolidin-1-yl]methyl]-1,3-thiazol-2-yl]amino]ethyl]-3-cyclopropyl-2-fluoranyl-prop-2-enamide | non-polymer | 553.5 | 2 | Chemie (A1ISG) PubChem (172643402) | |||
| 4 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ser 129 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57004.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1779.5 | |
| All* | Total formula weight | 58783.7 |
