9H0K

Crystal structure of human CREBBP histone acetyltransferase domain in complex with Propionyl- Coenzyme A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CREB-binding protein	polymer	348	40486.0	2	UniProt (Q92793) Pfam (PF08214)	Homo sapiens (human)	Histone lysine acetyltransferase CREBBP,Protein lactyltransferas CREBBP,Protein-lysine acetyltransferase CREBBP
2	C, D (A, B)	propionyl Coenzyme A	non-polymer		823.6	2	Chemie (1VU)
3	E (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	F, G (A, B)	water	water		18.0	437	Chemie (HOH)

Sequence modifications

A, B: 1322 - 1555 (UniProt: Q92793)

PDB	External Database	Details
Met 1296	-	initiating methionine
Gly 1297	-	expression tag
Ser 1298	-	expression tag
Ser 1299	-	expression tag
His 1300	-	expression tag
His 1301	-	expression tag
His 1302	-	expression tag
His 1303	-	expression tag
His 1304	-	expression tag
His 1305	-	expression tag
Asp 1306	-	expression tag
Tyr 1307	-	expression tag
Asp 1308	-	expression tag
Ile 1309	-	expression tag
Pro 1310	-	expression tag
Thr 1311	-	expression tag
Thr 1312	-	expression tag
Glu 1313	-	expression tag
Asn 1314	-	expression tag
Leu 1315	-	expression tag
Tyr 1316	-	expression tag
Phe 1317	-	expression tag
Gln 1318	-	expression tag
Gly 1319	-	expression tag
His 1320	-	expression tag
Thr 1321	-	expression tag
Phe 1503	Tyr 1503	engineered mutation

A, B: 1617 - 1699 (UniProt: Q92793)

PDB	External Database	Details
Ser 1556	-	linker
Gly 1613	-	linker
Gly 1614	-	linker
Ser 1615	-	linker
Gly 1616	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80972.0
Non-Polymers*	Number of molecules	3
	Total formula weight	1743.3
All*	Total formula weight	82715.2

*Water molecules are not included.