9H02
Crystal structure of human CREBBP histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CREB-binding protein | polymer | 348 | 40486.0 | 1 | UniProt (Q92793) Pfam (PF08214) | Homo sapiens (human) | Histone lysine acetyltransferase CREBBP,Protein lactyltransferas CREBBP,Protein-lysine acetyltransferase CREBBP |
| 2 | B (A) | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | non-polymer | 994.8 | 1 | Chemie (01K) PubChem (44571034) PubChem (23727984) PubChem (74110174) PubChem (10235064) PubChem (168311718) PubChem (172107380) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | I (A) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 1322 - 1555 (UniProt: Q92793)
A: 1617 - 1699 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Met 1296 | - | initiating methionine |
| Gly 1297 | - | expression tag |
| Ser 1298 | - | expression tag |
| Ser 1299 | - | expression tag |
| His 1300 | - | expression tag |
| His 1301 | - | expression tag |
| His 1302 | - | expression tag |
| His 1303 | - | expression tag |
| His 1304 | - | expression tag |
| His 1305 | - | expression tag |
| Asp 1306 | - | expression tag |
| Tyr 1307 | - | expression tag |
| Asp 1308 | - | expression tag |
| Ile 1309 | - | expression tag |
| Pro 1310 | - | expression tag |
| Thr 1311 | - | expression tag |
| Thr 1312 | - | expression tag |
| Glu 1313 | - | expression tag |
| Asn 1314 | - | expression tag |
| Leu 1315 | - | expression tag |
| Tyr 1316 | - | expression tag |
| Phe 1317 | - | expression tag |
| Gln 1318 | - | expression tag |
| Gly 1319 | - | expression tag |
| His 1320 | - | expression tag |
| Thr 1321 | - | expression tag |
| Phe 1503 | Tyr 1503 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1556 | - | linker |
| Gly 1613 | - | linker |
| Gly 1614 | - | linker |
| Ser 1615 | - | linker |
| Gly 1616 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40486.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1367.2 | |
| All* | Total formula weight | 41853.2 |
