9GZO
Cryo-EM structure of the human mitochondrial RNA polymerase transcription initiation complex (POLRMT/TFB2M/DNA/RNA) without TFAM; and with a slipped 3-mer RNA, pppGpGpA (slipped IC3-TFAM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA-directed RNA polymerase, mitochondrial | polymer | 1188 | 134632.3 | 1 | UniProt (O00411) Pfam (PF14700) Pfam (PF00940) | Homo sapiens (human) | MtRPOL |
| 2 | B (N) | Non-template strand DNA (56-MER) | polymer | 63 | 19652.6 | 1 | synthetic construct | ||
| 3 | C (T) | Template strand DNA (56-MER) | polymer | 62 | 18867.1 | 1 | synthetic construct | ||
| 4 | D (B) | Dimethyladenosine transferase 2, mitochondrial | polymer | 337 | 38901.3 | 1 | UniProt (Q9H5Q4) Pfam (PF00398) | Homo sapiens (human) | Hepatitis C virus NS5A-transactivated protein 5,HCV NS5A-transactivated protein 5,Mitochondrial 12S rRNA dimethylase 2,Mitochondrial transcription factor B2,h-mtTFB,h-mtTFB2,hTFB2M,mtTFB2,S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase 2 |
| 5 | E (R) | RNA (5'-D(*(GTP))-R(P*GP*A)-3') | polymer | 3 | 1134.6 | 1 | synthetic construct |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 213188.1 | |
| All* | Total formula weight | 213188.1 |
