9GYF

Ku70/80 with PAXX peptide mutation K193R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	X-ray repair cross-complementing protein 6	polymer	609	69945.0	1	UniProt (P12956) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF02037)	Homo sapiens (human)	5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
2	B (B)	X-ray repair cross-complementing protein 5	polymer	732	82812.4	1	UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785)	Homo sapiens (human)	86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
3	C (C)	Protein PAXX	polymer	23	2394.7	1	UniProt (Q9BUH6)	Homo sapiens	Paralog of XRCC4 and XLF,XRCC4-like small protein
4	D (D)	DNA1	polymer	15	4544.0	1		Homo sapiens
5	E (E)	DNA2	polymer	16	4962.2	1		Homo sapiens
6	F (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)

Sequence modifications

C: 180 - 202 (UniProt: Q9BUH6)

PDB	External Database	Details
Arg 193	Lys 193	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	164658.4
Non-Polymers*	Number of molecules	1
	Total formula weight	95.0
All*	Total formula weight	164753.3

*Water molecules are not included.