9GU2
Human adult muscle nAChR in desensitised state in nanodisc with 100 uM acetylcholine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, L) | Acetylcholine receptor subunit alpha | polymer | 437 | 49747.6 | 2 | UniProt (P02708) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 2 | B (B) | Acetylcholine receptor subunit beta | polymer | 478 | 54596.5 | 1 | UniProt (P11230) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 3 | C (D) | Acetylcholine receptor subunit delta | polymer | 496 | 56915.4 | 1 | UniProt (Q07001) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 4 | D (E) | Acetylcholine receptor subunit epsilon,Green fluorescent protein | polymer | 721 | 80603.8 | 1 | UniProt (Q04844) UniProt (P42212) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 5 | F, H (C, G) | Fab35 light chain | polymer | 213 | 23393.0 | 2 | Rattus norvegicus | ||
| 6 | G, I (F, H) | Fab35 heavy chain | polymer | 219 | 23879.8 | 2 | Rattus norvegicus | ||
| 7 | J, O (I, O) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G55220VL) | |||
| 8 | K, N (J, N) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 9 | L (K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 1 | In PDB GlyTouCan (G53168IY) | |||
| 10 | M (M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 11 | P, R (A, L) | ACETYLCHOLINE | non-polymer | 146.2 | 2 | Chemie (ACH) | |||
| 12 | Q (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 13 | S (L) | COPPER (II) ION | non-polymer | 63.5 | 1 | Chemie (CU) | |||
| 14 | T, U, V, W, X... (A, B, D, E, L...) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
E: 1 - 333 (UniProt: Q04844)
E: 333 - 342 (UniProt: P42212)
E: 342 - 473 (UniProt: Q04844)
E: 333 - 342 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| Leu 336 | Phe 64 | conflict |
| Thr 336 | Ser 65 | conflict |
| Leu 342 | His 231 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 333 | - | linker |
| Pro 333 | - | linker |
| Pro 333 | - | linker |
| Val 333 | - | linker |
| Ala 333 | - | linker |
| Thr 333 | - | linker |
| Met 333 | - | linker |
| Val 333 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 386156.4 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 5668.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 577.2 | |
| All* | Total formula weight | 392401.7 |
