9GU1
Human adult muscle nAChR in resting state in nanodisc with alpha-bungarotoxin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, K (A, L) | Acetylcholine receptor subunit alpha | polymer | 437 | 49747.6 | 2 | UniProt (P02708) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 2 | B (B) | Acetylcholine receptor subunit beta | polymer | 478 | 54596.5 | 1 | UniProt (P11230) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 3 | C, G (C, G) | Fab35 light chain | polymer | 213 | 23393.0 | 2 | Rattus norvegicus | ||
| 4 | D (D) | Acetylcholine receptor subunit delta | polymer | 496 | 56915.4 | 1 | UniProt (Q07001) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 5 | E (E) | Acetylcholine receptor subunit epsilon,Green fluorescent protein | polymer | 721 | 80603.8 | 1 | UniProt (Q04844) UniProt (P42212) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 6 | F, H (F, H) | Fab35 heavy chain | polymer | 219 | 23879.8 | 2 | Rattus norvegicus | ||
| 7 | I, J (I, J) | Alpha-bungarotoxin | polymer | 74 | 8005.3 | 2 | UniProt (P60615) | Bungarus multicinctus (many-banded krait) | Alpha-Bgtx,Alpha-Btx,Alpha-bungarotoxin,isoform A31,Alpha-BTX A31,Alpha-BgTx(A31),Alpha-bungarotoxin (A31),BGTX A31,Alpha-elapitoxin-Bm2a,Alpha-EPTX-Bm2a,Long neurotoxin 1 |
| 8 | L (K) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G63337SS) | |||
| 9 | M (M) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 10 | N (N) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 11 | O (O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 12 | P (P) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 13 | Q (Q) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G34499SX) | |||
| 14 | R (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 15 | S (L) | COPPER (II) ION | non-polymer | 63.5 | 1 | Chemie (CU) | |||
| 16 | AA, BA, CA, DA, T... (H, I, J, L, A...) | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence modifications
E: 1 - 312 (UniProt: Q04844)
E: 312 - 321 (UniProt: P42212)
E: 321 - 473 (UniProt: Q04844)
E: 312 - 321 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| Leu 314 | Phe 64 | conflict |
| Thr 315 | Ser 65 | conflict |
| Leu 321 | His 231 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 312 | - | linker |
| Pro 312 | - | linker |
| Pro 312 | - | linker |
| Val 312 | - | linker |
| Ala 312 | - | linker |
| Thr 312 | - | linker |
| Met 312 | - | linker |
| Val 312 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 402166.9 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 5789.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 284.8 | |
| All* | Total formula weight | 408240.9 |
