9GTW
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 3g
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysosomal alpha-glucosidase | polymer | 952 | 105448.5 | 1 | UniProt (P10253) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (human) | Acid maltase,Aglucosidase alfa |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | G (A) | (2~{S},3~{S},4~{S},5~{S})-2-heptyl-5-(hydroxymethyl)pyrrolidine-3,4-diol | non-polymer | 231.3 | 1 | Chemie (A1IPC) PubChem (52939731) | |||
| 7 | H, I, J, K, L (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 8 | M, N, O (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 9 | P, Q (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 10 | R, S, T, V (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 11 | U (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 12 | AA, BA, CA, DA, EA... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 13 | IA (A) | water | water | 18.0 | 692 | Chemie (HOH) |
Sequence modifications
A: 1 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | variant |
| His 223 | Arg 223 | variant |
| Ile 780 | Val 780 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 105448.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1581.5 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2896.2 | |
| All* | Total formula weight | 109926.2 |
