9GSV
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4c
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysosomal alpha-glucosidase | polymer | 952 | 105448.5 | 1 | UniProt (P10253) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (human) | Acid maltase,Aglucosidase alfa |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C, E (C, E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F (F) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | G (A) | (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-(2-phenylethyl)piperidine-3,4,5-triol | non-polymer | 267.3 | 1 | Chemie (A1IO6) | |||
| 7 | H, I, J (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 8 | K, L, M, N, O (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 9 | P, Q (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 10 | R, S (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 11 | AA, BA, CA, T, U... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 12 | DA (A) | water | water | 18.0 | 475 | Chemie (HOH) |
Sequence modifications
A: 1 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | variant |
| His 223 | Arg 223 | variant |
| Ile 780 | Val 780 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 105448.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2535.4 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2042.3 | |
| All* | Total formula weight | 110026.1 |
