9GSH
Cryo-EM structure of PMCA-NPTN complex captured in E1-Ca-ATP state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasma membrane calcium-transporting ATPase 2 | polymer | 1214 | 134647.1 | 1 | UniProt (Q9R0K7) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00702) Pfam (PF00689) Pfam (PF12424) | Mus musculus (house mouse) | PMCA2,Plasma membrane calcium ATPase isoform 2,Plasma membrane calcium pump isoform 2 |
| 2 | B (B) | Neuroplastin | polymer | 413 | 46440.1 | 1 | UniProt (P97300) Pfam (PF07679) Pfam (PF13927) | Mus musculus (house mouse) | Stromal cell-derived receptor 1,SDR-1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 1 | Chemie (KXP) | |||
| 7 | G, H, I, J, K... (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A: 1 - 1198 (UniProt: Q9R0K7)
B: 1 - 397 (UniProt: P97300)
| PDB | External Database | Details |
|---|---|---|
| Glu 1199 | - | expression tag |
| Asn 1200 | - | expression tag |
| Leu 1201 | - | expression tag |
| Tyr 1202 | - | expression tag |
| Phe 1203 | - | expression tag |
| Gln 1204 | - | expression tag |
| Gly 1205 | - | expression tag |
| Gly 1206 | - | expression tag |
| Asp 1207 | - | expression tag |
| Tyr 1208 | - | expression tag |
| Lys 1209 | - | expression tag |
| Asp 1210 | - | expression tag |
| Asp 1211 | - | expression tag |
| Asp 1212 | - | expression tag |
| Asp 1213 | - | expression tag |
| Lys 1214 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 398 | - | expression tag |
| Asn 399 | - | expression tag |
| Leu 400 | - | expression tag |
| Tyr 401 | - | expression tag |
| Phe 402 | - | expression tag |
| Gln 403 | - | expression tag |
| Gly 404 | - | expression tag |
| Gly 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 181087.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2944.9 | |
| All* | Total formula weight | 184032.1 |
