9GR0

Interaction with AK2A links AIFM1 to cellular energy metabolism. The cryo-EM structure of dimeric AIFM1 bound by AK2A.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, F)	Adenylate kinase 2, mitochondrial	polymer	239	26516.8	2	UniProt (P54819) Pfam (PF00406) Pfam (PF05191)	Homo sapiens (human)	AK 2,ATP-AMP transphosphorylase 2,ATP:AMP phosphotransferase,Adenylate monophosphate kinase
2	C, D (B, C)	Apoptosis-inducing factor 1, mitochondrial	polymer	540	58902.8	2	UniProt (O95831) Pfam (PF00070) Pfam (PF14721)	Homo sapiens (human)	Programmed cell death protein 8
3	E, G (B, C)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	F, H (B, C)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
5	I, J (B, C)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

B, C: 103 - 613 (UniProt: O95831)

PDB	External Database	Details
Met 85	-	initiating methionine
Ala 86	-	expression tag
Ser 87	-	expression tag
Met 88	-	expression tag
Thr 89	-	expression tag
Gly 90	-	expression tag
Gly 91	-	expression tag
Gln 92	-	expression tag
Gln 93	-	expression tag
Met 94	-	expression tag
Gly 95	-	expression tag
Arg 96	-	expression tag
Gly 97	-	expression tag
Ser 98	-	expression tag
Glu 99	-	expression tag
Phe 100	-	expression tag
Met 101	-	expression tag
Gly 102	-	expression tag
Ala 614	-	expression tag
Ala 615	-	expression tag
Ala 616	-	expression tag
Leu 617	-	expression tag
Glu 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170839.3
Non-Polymers*	Number of molecules	4
	Total formula weight	2897.9
All*	Total formula weight	173737.2

*Water molecules are not included.