9GQZ
Interaction with AK2A links AIFM1 to cellular energy metabolism. The cryo-EM structure of dimeric AIFM1 engaged to MIA40.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, F) | Mitochondrial intermembrane space import and assembly protein 40 | polymer | 150 | 17050.4 | 2 | UniProt (Q8N4Q1) Pfam (PF06747) | Homo sapiens (human) | Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 |
| 2 | C, D (B, C) | Apoptosis-inducing factor 1, mitochondrial | polymer | 540 | 58902.8 | 2 | UniProt (O95831) Pfam (PF00070) Pfam (PF14721) | Homo sapiens (human) | Programmed cell death protein 8 |
| 3 | E, G (B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 4 | F, H (B, C) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 5 | I, J (B, C) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 142 (UniProt: Q8N4Q1)
B, C: 103 - 613 (UniProt: O95831)
| PDB | External Database | Details |
|---|---|---|
| Ser 53 | Cys 53 | conflict |
| Ser 55 | Cys 55 | conflict |
| Leu 143 | - | expression tag |
| Glu 144 | - | expression tag |
| His 145 | - | expression tag |
| His 146 | - | expression tag |
| His 147 | - | expression tag |
| His 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 85 | - | initiating methionine |
| Ala 86 | - | expression tag |
| Ser 87 | - | expression tag |
| Met 88 | - | expression tag |
| Thr 89 | - | expression tag |
| Gly 90 | - | expression tag |
| Gly 91 | - | expression tag |
| Gln 92 | - | expression tag |
| Gln 93 | - | expression tag |
| Met 94 | - | expression tag |
| Gly 95 | - | expression tag |
| Arg 96 | - | expression tag |
| Gly 97 | - | expression tag |
| Ser 98 | - | expression tag |
| Glu 99 | - | expression tag |
| Phe 100 | - | expression tag |
| Met 101 | - | expression tag |
| Gly 102 | - | expression tag |
| Ala 614 | - | expression tag |
| Ala 615 | - | expression tag |
| Ala 616 | - | expression tag |
| Leu 617 | - | expression tag |
| Glu 618 | - | expression tag |
| His 619 | - | expression tag |
| His 620 | - | expression tag |
| His 621 | - | expression tag |
| His 622 | - | expression tag |
| His 623 | - | expression tag |
| His 624 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 151906.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2897.9 | |
| All* | Total formula weight | 154804.4 |
