9GPY
The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 12g/j
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 128 | 14004.0 | 3 | UniProt (Q13451) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 2 | D, F, H (A, B, C) | 2-cyclohexyl-18,19-dimethoxy-13-methyl-11,17-dioxa-4-aza-1lambda5,18lambda5-diphospha-1,15-distannatetracyclo[13.4.0.04,9.016,20]nonadecane-3,10-quinone | non-polymer | 568.7 | 3 | Chemie (A1INZ) | |||
| 3 | E, G, I (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B, C: 16 - 140 (UniProt: Q13451)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Thr 19 | Ala 19 | engineered mutation |
| Ala 103 | Cys 103 | engineered mutation |
| Ile 107 | Cys 107 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42012.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1892.3 | |
| All* | Total formula weight | 43904.4 |
