9GJQ

Crystal structure of humanised cereblon from Magnetospirillum gryphiswaldense bound by dihydrouracil-indole compound [1-(1H-indol-6-yl)dihydro-2,4(1H,3H)-pyrimidinedione].

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cereblon isoform 4	polymer	109	12043.5	1	UniProt (A4TVL0)	Magnetospirillum gryphiswaldense
2	B (A)	1-(1H-indol-6-yl)-1,3-diazinane-2,4-dione	non-polymer		229.2	1	Chemie (A1IMN)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

A: 18 - 124 (UniProt: A4TVL0)

PDB	External Database	Details
Gly 16	-	expression tag
Ser 17	-	expression tag
His 52	Ala 52	engineered mutation
Tyr 54	Met 54	engineered mutation
His 56	Phe 56	engineered mutation
His 77	Phe 77	engineered mutation
Phe 101	Tyr 101	engineered mutation
Ala 117	Arg 117	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	12043.5
Non-Polymers*	Number of molecules	2
	Total formula weight	294.6
All*	Total formula weight	12338.2

*Water molecules are not included.