9GJN

ERAP1 in complex with 1-[2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl)acetamido]cyclohexane-1-carboxylic acid

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Endoplasmic reticulum aminopeptidase 1	polymer	922	105343.4	2	UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (human)	ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
2	C, S (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, T (A, B)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	2	Chemie (B3P)
4	E, F, G, H, I... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	12	Chemie (EDO)
5	M, N, O, P, Q (A)	BROMIDE ION	non-polymer		79.9	5	Chemie (BR)
6	R, Y (A, B)	1-[2-(3-oxidanylidene-1,4-benzothiazin-4-yl)ethanoylamino]cyclohexane-1-carboxylic acid	non-polymer		348.4	2	Chemie (A1IMK)
7	AA, Z (B, A)	water	water		18.0	1756	Chemie (HOH)

Sequence modifications

A, B: 1 - 485 (UniProt: Q9NZ08)

PDB	External Database	Details
Gln 70	Asn 70	conflict
Gln 154	Asn 154	conflict
Gln 414	Asn 414	conflict

A, B: 514 - 941 (UniProt: Q9NZ08)

PDB	External Database	Details
Gly 511	-	linker
Ser 512	-	linker
Gly 513	-	linker
Gln 760	Asn 760	conflict
Glu 942	-	expression tag
Asn 943	-	expression tag
Leu 944	-	expression tag
Tyr 945	-	expression tag
Phe 946	-	expression tag
Gln 947	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	210686.8
Non-Polymers*	Number of molecules	23
	Total formula weight	2536.7
All*	Total formula weight	213223.5

*Water molecules are not included.