9GIY

Structure of the human mitochondrial pyruvate carrier inhibited by mitoglitazone

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitochondrial pyruvate carrier 1-like protein	polymer	136	15155.5	1	UniProt (P0DKB6) Pfam (PF03650)	Homo sapiens (human)
2	B (B)	Mitochondrial pyruvate carrier 2	polymer	133	15093.7	1	UniProt (O95563) Pfam (PF03650)	Homo sapiens (human)	Brain protein 44
3	C (C)	Macrobody,Maltose/maltodextrin-binding periplasmic protein	polymer	515	56307.0	1	UniProt (P0AEY0) Pfam (PF01547)	synthetic construct	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP
4	D (B)	Mitoglitazone	non-polymer		370.4	1	Chemie (LO7)
5	E (B)	Mitoglitazone (R-form)	non-polymer		370.4	1	Chemie (A1IMZ)

Sequence modifications

B: 1 - 127 (UniProt: O95563)

PDB	External Database	Details
Glu 128	-	expression tag
Asn 129	-	expression tag
Leu 130	-	expression tag
Tyr 131	-	expression tag
Phe 132	-	expression tag
Gln 133	-	expression tag

C: 1 - 131 (PDB: 9GIY)
C: 132 - 491 (UniProt: P0AEY0)

PDB	External Database	Details
Pro 492	-	expression tag
Gly 493	-	expression tag
Ser 494	-	expression tag
Pro 495	-	expression tag
Asp 496	-	expression tag
Ala 497	-	expression tag
Ala 498	-	expression tag
Ile 499	-	expression tag
Glu 500	-	expression tag
Gly 501	-	expression tag
Arg 502	-	expression tag
Thr 503	-	expression tag
Ser 504	-	expression tag
Glu 505	-	expression tag
Asp 506	-	expression tag
Ala 507	-	expression tag
Trp 508	-	expression tag
Ser 509	-	expression tag
His 510	-	expression tag
Pro 511	-	expression tag
Gln 512	-	expression tag
Phe 513	-	expression tag
Glu 514	-	expression tag
Lys 515	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	86556.3
Non-Polymers*	Number of molecules	2
	Total formula weight	740.8
All*	Total formula weight	87297.2

*Water molecules are not included.