9GIO
Crystal structure of the VHL-EloC-EloB complex with a covalent compound bound to C77 of VHL.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Elongin-B | polymer | 107 | 12030.7 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (B) | Isoform 2 of Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369-2) Pfam (PF03931) UniProt (by SIFTS) (Q15369) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (C) | von Hippel-Lindau disease tumor suppressor | polymer | 160 | 18558.2 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | D (C) | N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide | non-polymer | 472.6 | 1 | Chemie (3JF) | |||
| 5 | E (C) | N-[2-(dimethylsulfamoyl)-5-[(1-methylpyrazol-4-yl)methoxy]phenyl]propanamide | non-polymer | 366.4 | 1 | Chemie (A1IMD) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 339 | Chemie (HOH) |
Sequence modifications
A: 1 - 104 (UniProt: Q15370)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 41432.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 839.0 | |
| All* | Total formula weight | 42271.3 |
