9GHI
Machupo virus GP1-GP2 heterodimer in complex with Fab of MAC1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pre-glycoprotein polyprotein GP complex | polymer | 204 | 23546.8 | 1 | UniProt (Q8AZ57) UniProt (by SIFTS) (Q6IUF7) | Mammarenavirus machupoense | Pre-GP-C |
| 2 | B (B) | Glycoprotein G2 | polymer | 204 | 23122.9 | 1 | UniProt (Q6IUF7) | Mammarenavirus machupoense | GP2 |
| 3 | C (H) | MAC1 heavy chain | polymer | 234 | 25248.1 | 1 | Mus musculus | ||
| 4 | D (L) | MAC1 light chain | polymer | 217 | 24090.6 | 1 | Mus musculus | ||
| 5 | E, F (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G42466VF) | |||
| 7 | H (F) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 8 | I (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | J, K (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | L, M, N, O (A, B, H, L) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 59 - 262 (UniProt: Q8AZ57)
B: 263 - 428 (UniProt: Q6IUF7)
| PDB | External Database | Details |
|---|---|---|
| Cys 88 | Leu 88 | engineered mutation |
| Ala 138 | Lys 138 | conflict |
| Glu 227 | Asp 227 | conflict |
| Ser 258 | Glu 258 | engineered mutation |
| Arg 260 | Ser 260 | engineered mutation |
| Lys 261 | Leu 261 | engineered mutation |
| Arg 262 | Lys 262 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 263 | Ala 263 | engineered mutation |
| Asp 307 | Asn 307 | conflict |
| Pro 332 | Glu 332 | engineered mutation |
| Cys 340 | Leu 340 | engineered mutation |
| Ser 429 | - | expression tag |
| Gly 430 | - | expression tag |
| Asp 431 | - | expression tag |
| Asp 432 | - | expression tag |
| Asp 433 | - | expression tag |
| Asp 434 | - | expression tag |
| Lys 435 | - | expression tag |
| Gly 436 | - | expression tag |
| Ser 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Trp 439 | - | expression tag |
| Ser 440 | - | expression tag |
| His 441 | - | expression tag |
| Pro 442 | - | expression tag |
| Gln 443 | - | expression tag |
| Phe 444 | - | expression tag |
| Glu 445 | - | expression tag |
| Lys 446 | - | expression tag |
| Gly 447 | - | expression tag |
| Gly 448 | - | expression tag |
| Gly 449 | - | expression tag |
| Ser 450 | - | expression tag |
| Gly 451 | - | expression tag |
| Gly 452 | - | expression tag |
| Gly 453 | - | expression tag |
| Ser 454 | - | expression tag |
| Gly 455 | - | expression tag |
| Gly 456 | - | expression tag |
| Ser 457 | - | expression tag |
| Ala 458 | - | expression tag |
| Trp 459 | - | expression tag |
| Ser 460 | - | expression tag |
| His 461 | - | expression tag |
| Pro 462 | - | expression tag |
| Gln 463 | - | expression tag |
| Phe 464 | - | expression tag |
| Glu 465 | - | expression tag |
| Lys 466 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96008.4 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3078.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 99529.6 |
