9GGP

Alpha-1-antitrypsin in complex with the Fab fragment of an anti-polymer antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-1-antitrypsin	polymer	404	45611.7	2	UniProt (P01009) Pfam (PF00079)	Homo sapiens (human)	Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1
2	C (H)	Fab fragment heavy chain of 2C1 monoclonal antibody	polymer	222	23874.7	1		Mus musculus
3	D (L)	Fab fragment light chain of 2C1 monoclonal antibody	polymer	212	23495.0	1		Mus musculus
4	E, F, G (A, H)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	H, I, J, K (A, B, H, L)	water	water		18.0	610	Chemie (HOH)

Sequence modifications

A, B: 2 - 394 (UniProt: P01009)

PDB	External Database	Details
Met -9	-	initiating methionine
Arg -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Thr 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138593.1
Non-Polymers*	Number of molecules	3
	Total formula weight	186.2
All*	Total formula weight	138779.4

*Water molecules are not included.