9GG9

HUMAN PI3KGAMMA IN COMPLEX WITH ISOCUMARIN INHIBITOR 11

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	polymer	980	112098.7	1	UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI3-kinase subunit gamma,PI3K-gamma,PI3Kgamma,PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,PtdIns-3-kinase subunit p110-gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p120-PI3K
2	B (A)	3-[(1~{S})-1-[4-azanyl-3-(3-fluoranyl-5-oxidanyl-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-phenyl-isochromen-1-one	non-polymer		493.5	1	Chemie (A1IKW)
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E (A)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 144 - 1102 (UniProt: P48736)

PDB	External Database	Details
Met 139	-	initiating methionine
Leu 140	-	expression tag
Leu 141	-	expression tag
Gly 142	-	expression tag
Ser 143	-	expression tag
Glu 1103	-	expression tag
Phe 1104	-	expression tag
Gly 1105	-	expression tag
Leu 1106	-	expression tag
Val 1107	-	expression tag
Pro 1108	-	expression tag
Arg 1109	-	expression tag
Gly 1110	-	expression tag
Ser 1111	-	expression tag
Gly 1112	-	expression tag
His 1113	-	expression tag
His 1114	-	expression tag
His 1115	-	expression tag
His 1116	-	expression tag
His 1117	-	expression tag
His 1118	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	112098.7
Non-Polymers*	Number of molecules	3
	Total formula weight	685.6
All*	Total formula weight	112784.3

*Water molecules are not included.