9GG7
Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS324 peptide and covalent stabilizer 187
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein sigma | polymer | 236 | 26553.9 | 2 | UniProt (P31947) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | C, D (C, P) | Isoform Tau-G of Microtubule-associated protein tau | polymer | 14 | 1564.7 | 2 | UniProt (P10636) | Homo sapiens | Neurofibrillary tangle protein,Paired helical filament-tau,PHF-tau |
| 3 | E, F (A, B) | 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde | non-polymer | 302.3 | 2 | Chemie (TW8) | |||
| 4 | G, H, I, J (A, B, C, P) | water | water | 18.0 | 398 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 38 | Cys 38 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 56237.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 604.7 | |
| All* | Total formula weight | 56841.9 |
